Addition of dithiols to bis-ynones: development of a versatile platform for the synthesis of polyketide natural products.
نویسندگان
چکیده
[reaction: see text] The conjugate addition of dithiols to bis-ynones generates a versatile masked 1,3,5-triketone platform. These functional units are useful intermediates for the synthesis of oxygen-containing heterocycles commonly found in polyketide natural products. The tetrahydropyranyl fragments of the marine macrolides Lyngbouilloside and Callipeltoside A have been synthesized with use of this methodology.
منابع مشابه
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عنوان ژورنال:
- Organic letters
دوره 5 7 شماره
صفحات -
تاریخ انتشار 2003